The Fanatics Collectibles Regent Street store will be 803 square metres in size and will be open seven days a week.
A central display will showcase some of the rarest and most desirable trading cards, with a giant suspended circular screen above.
The store will have thousands of unique items, including single cards, retail boxes and high-end hobby releases.
There will be monthly trade nights, kids rip events, athlete signings and appearances, partner activations and grading drop-off, all designed to build a community of collectors and fans.
The store will be home to a number of trading-card products, including sports (soccer, football, baseball, F1, basketball, UFC, WWE), sports gaming cards (Match Attax) and entertainment (Disney, Marvel, Star Wars, Pixar, Garbage Pail Kids, Stranger Things).
The organisation has secured long-term, exclusive rights to design, manufacture, and distribute trading cards for several sports and entertainment properties including MLB, MLBPA, the Premier League, MLS, UFC, Formula 1, as well as Disney, Marvel, Pixar, and Star Wars.